Czech Infrastructure for Integrative Structural Biology (CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Publikace
Počet publikací: 168
2022
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A large-scale assay library for targeted protein quantification in renal cell carcinoma tissues
Proteomics, rok: 2022, ročník: 22, vydání: 7, DOI
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A release of Ti-ions from nanostructured titanium oxide surfaces
Surfaces and Interfaces, rok: 2022, ročník: 29, vydání: April 2022, DOI
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Aminophylline Induces Two Types of Arrhythmic Events in Human Pluripotent Stem Cell–Derived Cardiomyocytes
Frontiers in Pharmacology, rok: 2022, ročník: 12, vydání: January, DOI
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Atomic Force Spectroscopy is a promising tool to study contractile properties of cardiac cells
Micron, rok: 2022, DOI
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Cancer cell viscoelasticity measurement by quantitative phase and flow stress induction
Biophysical Journal, rok: 2022, ročník: 121, vydání: 9, DOI
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Celleriite, ☐(Mn22+Al)Al6(Si6O18)(BO3)3(OH)3(OH), a new mineral species of the tourmaline supergroup
American Mineralogist, rok: 2022, ročník: 107, vydání: 1, DOI
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Critical interactions of neuronal transcription factor REST with stabilizer TRF2
Rok: 2022, druh: Konferenční abstrakty
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Detailed analysis of binding sites in the PLL family
Rok: 2022, druh: Konferenční abstrakty
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Characterisation of Waterborne Psychrophilic Massilia Isolates with Violacein Production and Description of Massilia antarctica sp. nov.
Microorganisms, rok: 2022, ročník: 10, vydání: 4, DOI
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Characterization of the AGR2 Interactome Uncovers New Players of Protein Disulfide Isomerase Network in Cancer Cells
Molecular & Cellular Proteomics, rok: 2022, ročník: 21, vydání: 2, DOI