Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
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Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 319
2024
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Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities
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Merging Bambus[6]uril and Biotin[6]uril into an Enantiomerically Pure Monofunctionalized Hybrid Macrocycle
Organic Letters, rok: 2024, ročník: 26, vydání: 1, DOI
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Structure and replication cycle of a virus infecting climate-modulating alga <i>Emiliania huxleyi</i>
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Visible-Light-Activated Carbon Monoxide Release from Porphyrin-Flavonol Hybrids
Journal of the American Chemical Society, rok: 2024, ročník: 146, vydání: 1, DOI
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W18O49 Nanowhiskers Decorating SiO2 Nanofibers: Lessons from In Situ SEM/TEM Growth to Large Scale Synthesis and Fundamental Structural Understanding
CRYSTAL GROWTH & DESIGN, rok: 2024, ročník: 24, vydání: 1, DOI
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WS2 fullerene/plate nanofibers: The tunable crossroad between dimensionalities
2023
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A color-tunable single-benzene fluorophore-based sensor for sensitive detection of palladium in solution and living cells
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A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody
CELL REPORTS, rok: 2023, ročník: 42, vydání: 9, DOI
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A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis
Plant Direct, rok: 2023, ročník: 7, vydání: 3, DOI
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A thermosensitive gel matrix for bioreactor-assisted in-cell NMR of nucleic acids and proteins
Journal of biomolecular NMR, rok: 2023, ročník: 77, vydání: 5-6, DOI