Czech Infrastructure for Integrative Structural Biology (CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 271
2022
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Critical interactions of neuronal transcription factor REST with stabilizer TRF2
Rok: 2022, druh: Konferenční abstrakty
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Cryo-electron microscopy and image classification reveal the existence and structure of the coxsackievirus A6 virion
Communications Biology, rok: 2022, ročník: 5, vydání: 1, DOI
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Describing 14-3-3 dimerization: tools to obtain KD
Rok: 2022, druh: Konferenční abstrakty
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Detailed analysis of binding sites in the PLL family
Rok: 2022, druh: Konferenční abstrakty
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Diethyl ether anesthesia induces transient cytosolic [Ca2+] increase, heat shock proteins, and heat stress tolerance of photosystem II in Arabidopsis
Frontiers in Plant Science, rok: 2022, ročník: 13, vydání: SEP, DOI
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Differentiation of Sialyl Linkages Using a Combination of Alkyl Esterification and Phenylhydrazine Derivatization: Application for N-Glycan Profiling in the Sera of Patients with Lung Cancer
ANALYTICAL CHEMISTRY, rok: 2022, ročník: 94, vydání: 18, DOI
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Dual cardiomyocyte cluster detection the different types of arrhythmogenic potential of caffein
Rok: 2022, druh: Konferenční abstrakty
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Ecological specialization and reproductive isolation among closely related sympatric ant-eating spiders
Journal of Animal Ecology, rok: 2022, ročník: 91, vydání: 9, DOI
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Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice
Life Sciences, rok: 2022, ročník: 310, vydání: DEC, DOI
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Exkurze studentů Biskupského gymnázia
Rok: 2022, druh: Popularizační texty