Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
-
Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 249
2023
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Targeting undruggable oncoproteins c-Myc and N-Myc by the 9aaTADs
Rok: 2023, druh: Další prezentace na konferencích
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Tick-borne encephalitis: A comprehensive review of the epidemiology, virology, and clinical picture
Reviews in Medical Virology, rok: 2023, ročník: 33, vydání: 5, DOI
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Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology
BIOACTIVE MATERIALS, rok: 2023, ročník: 20, vydání: FEB, DOI
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Utility of RNA sequencing for transcriptome analysis of small extracellular vesicles derived from blood sera of colorectal cancer patients
Rok: 2023, druh: Konferenční abstrakty
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Vaccination against tick-borne encephalitis elicits a detectable NS1 IgG antibody response
Journal of Virological Methods, rok: 2023, ročník: 322, vydání: December, DOI
2022
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14-3-3 protein isoforms: mutual dimerization propensities screening kit
Rok: 2022, druh: Konferenční abstrakty
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35th NMR Valtice
Rok: 2022, druh: Uspořádání konference
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A large-scale assay library for targeted protein quantification in renal cell carcinoma tissues
Proteomics, rok: 2022, ročník: 22, vydání: 7, DOI
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Adamantane-Substituted Purine Nucleosides: Synthesis, Host-Guest Complexes with beta-Cyclodextrin and Biological Activity
International Journal of Molecular Sciences, rok: 2022, ročník: 23, vydání: 23, DOI
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Airborne Preparation of Small Gold Nanoparticles Dispersed on Mesoporous Silica for the Catalytic Oxidation of Glycerol to Dihydroxyacetone
ACS Applied Nano Materials, rok: 2022, ročník: 5, vydání: 12, DOI