Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant

Autoři	SALEK Cyril FOLBER František FRONKOVA Eva PECHERKOVA Pavla JELINKOVA Hana HRABOVSKÝ Štěpán HORACEK Jan M. CETKOVSKY Petr MAYER Jiří TRKA Jan DOUBEK Michael
Rok publikování	2022
Druh	Článek v odborném periodiku
Časopis / Zdroj	British journal of haematology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://onlinelibrary.wiley.com/doi/10.1111/bjh.17966
Doi	http://dx.doi.org/10.1111/bjh.17966
Klíčová slova	acute lymphoblastic leukaemia; minimal residual disease; prognostic factors; PCR; IG; TR rearrangements
Popis	The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74 center dot 0%, 42 center dot 3% and 35 center dot 0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0 center dot 32 and 2 center dot 25).