Protein cargo in extracellular vesicles as the key mediator in the progression of cancer

Logo poskytovatele
Logo poskytovatele
Logo poskytovatele


Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj Cell Communication and Signaling
Fakulta / Pracoviště MU

Lékařská fakulta

Klíčová slova Extracellular vesicles; Exosomes; Exosomal proteins; Cancer; Tumour microenvironment; Cancer-associated fibroblasts; Angiogenesis; Cell death; Immune evasion; Metastasis; Therapy resistance; Biomarkers
Přiložené soubory
Popis Exosomes are small vesicles of endosomal origin that are released by almost all cell types, even those that are pathologically altered. Exosomes widely participate in cell-to-cell communication via transferring cargo, including nucleic acids, proteins, and other metabolites, into recipient cells. Tumour-derived exosomes (TDEs) participate in many important molecular pathways and affect various hallmarks of cancer, including fibroblasts activation, modification of the tumour microenvironment (TME), modulation of immune responses, angiogenesis promotion, setting the pre-metastatic niche, enhancing metastatic potential, and affecting therapy sensitivity and resistance. The unique exosome biogenesis, composition, nontoxicity, and ability to target specific tumour cells bring up their use as promising drug carriers and cancer biomarkers. In this review, we focus on the role of exosomes, with an emphasis on their protein cargo, in the key mechanisms promoting cancer progression. We also briefly summarise the mechanism of exosome biogenesis, its structure, protein composition, and potential as a signalling hub in both normal and pathological conditions.A1Dxc4hLEvJAjvXsZVsCuzVideo Abstract
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info