Klastr zdraví

Code: HORIZON-HLTH-2024-STAYHLTH-01-02-two-stage
Action type: RIA
Opening: 30 Mar 2023
Deadline: 19 Sep 2023 (First Stage), 11 Apr 2024 (Second Stage)
Budget (EUR million): 30
Expected EU contribution per project (EUR million): 8 - 10
Number of projects expected to be funded: 3

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several impacts of destination 1 “Staying healthy in a rapidly changing society”. To that end, proposals under this topic should aim for delivering results that are directed at, tailored towards and contributing to all of the following expected outcomes:

• Children, adolescents and their parents/carers are educated and empowered in prevention strategies involving personalised approaches and solutions (also through the use of digital tools) to manage, maintain and improve children’s and adolescents' own health, physical activity, nutrition habits, leisure needs, mental and social well-being, in full respect of the privacy of individuals.
• Children and adolescents, including those from vulnerable contexts, monitor their health risks, adopt healthy lifestyles at home, at school and in the community and interact with their doctors and carers (receiving and providing feedback), also through the means of digitally enabled solutions, better health literacy, training and critical thinking.
• Thanks to better co-creation, training, digital and health literacy, children, adolescents, parents and carers across Europe access and use person-centred, widely available solutions for children and adolescents’ health, care and wellbeing, appropriate to a rapidly changing and increasingly digitalised society, also considering the risk of digital addiction.

Code: HORIZON-HLTH-2024-STAYHLTH-01-05-two-stage
Action type: RIA
Opening: 30 Mar 2023
Deadline: 19 Sep 2023 (First Stage), 11 Apr 2024 (Second Stage)
Budget (EUR million): 50
Expected EU contribution per project (EUR million): 8 - 12
Number of projects expected to be funded: 5

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several impacts of destination 1 “Staying healthy in a rapidly changing society”. To that end, proposals under this topic should aim at delivering results that are directed at, tailored towards and contributing to several of the following expected outcomes:

• Citizens have access to and use effective personalised prevention schemes and health counselling (including through digital means) that take into account their individual characteristics and situation. Individuals can be assigned to particular groups based on their characteristics, and receive advice adequate to that group. Stratification of a population into groups showing similar traits allows for effective personalised disease prevention.
• Health professionals use effective, tried and tested tools to facilitate their work when advising both patients and healthy individuals. Public health programme owners gain insight into the specificities and characteristics of disease clusters within the population through stratification. This can then be used to facilitate the identification of population groups with elevated risk of developing certain diseases and improve the programmes, update them and design effective strategies for optimal solutions and interventions.

Code: HORIZON-HLTH-2023-ENVHLTH-02-02
Action type: RIA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 30
Expected EU contribution per project (EUR million): 5 - 6
Number of projects expected to be funded: 5

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 2 ‘Living and working in a health-promoting environment’. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to most of the following expected outcomes:

• Public authorities and regulators are supported with evidence-based guidance to design occupational health policies;
• Public authorities, employers, organisations and social partners (e.g. trade unions and employer organisations) are better supported with tools, evidence-based intervention options and guidelines to promote mental and physical well-being and health in the workplace;
• Public authorities and the scientific community have access to FAIR data62 and robust evidence on direct links between psychosocial and physical risk factors at the workplace (considering also individual differences such as age, gender, cultural background, bodily/cognitive abilities) and specific health outcomes;
• Public authorities, regulators and social partners are informed by evidence on the costs, benefits, sustainability and expected challenges of available solutions;
• Public authorities and employers take advantage of the best available knowledge (including new innovations and ways for action) to support interventions and solutions on the design of the built working environment and promote healthier behaviours at the workplace;
• Public authorities and employers develop adequate measures to prevent and reduce the negative outcomes of exposure to psycho-social and physical risk factors in the workplace and support recovery;
• Workers are more protected against work-related hazards and informed about effective prevention approaches based on specific and appropriate measures and health enhancing behaviours;
• Workers living with a chronic disease and/or recovering from a mental of physical health problem are supported to continue/return to work.

Code: HORIZON-HLTH-2023-ENVHLTH-02-03
Action type: RIA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 40
Expected EU contribution per project (EUR million): 6 - 7
Number of projects expected to be funded: 7

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 2 ‘Living and working in a health-promoting environment’. To that end, proposals under this topic should aim for delivering results that are directed towards and contributing to all of the following expected outcomes:

• Public authorities including EU risk assessment bodies and regulators are supported with scientific evidence to implement the comprehensive European Union Framework on Endocrine Disruptors67, Chemicals Strategy for Sustainability Towards a Toxic-Free Environment68, EU legislation on plant protection products69 and EU occupational safety and health legislation70;
• Public authorities improve their risk assessment, management and communication through access to FAIR data71 and more robust evidence on the causal links between exposure to endocrine disruptors and health outcomes for which insufficient data exist;
• Research community has better data on the role of endocrine disruptors and other co-factors (e.g., lifestyle, behavioural, socio-economic) to enable a better understanding of their individual or combined health impacts;
• Public authorities and the scientific community take advantage of latest methodologies for advancing the understanding of health impact of exposures;
• Public authorities, employers and citizens rely on practical evidence-informed guidelines for exposure prevention and reduction;
• Citizens are engaged and informed about the health impact of exposures to endocrine disruptors and risk-preventing behaviours are promoted.

Code: HORIZON-HLTH-2023-ENVHLTH-02-04
Action type: CSA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 3
Expected EU contribution per project (EUR million): around 3
Number of projects expected to be funded: 1

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 2 ‘Living and working in a health-promoting environment’. To that end, proposals under this topic should aim for delivering results that are tailored towards and contributing to all of the following expected outcomes:

• Environment and health research community, research-policymaking authorities, research funders and other relevant stakeholders work together at the European and international level towards establishing a medium-long-term Global Human Exposome Network;
• Environment and health research community, authorities working at the science-policy interface and research funders provide options for functioning, financing and governance of a medium-long-term Global Human Exposome Network also considering the strengthening of the coordination of the European Human Exposome Network;
• Relevant stakeholders profit from a strengthened coordination and collaboration globally among different fields of research and innovation with relevance to deciphering the human exposome;
• A roadmap and a R&I agenda for international cooperation in specified areas of exposome research and innovation, including, among others, recommendations for exchange of knowledge and data, policy uptake, technological and conceptual approaches and promotion of global level coordinated initiatives on the exposome are made available to the relevant international stakeholders;
• The coordination of research initiatives, infrastructures, facilities and resources in the area of the Exposome in Europe is supported and reinforced;
• The interoperability and harmonisation between data and studies is increased facilitating the exchange and use of information across research disciplines and groups. Call - Environment and Health (two stage - 2024)

Code: HORIZON-HLTH-2024-ENVHLTH-02-06-two-stage
Action type: RIA
Opening: 30 Mar 2023
Deadline: 19 Sep 2023 (First Stage), 11 Apr 2024 (Second Stage)
Budget (EUR million): 60
Expected EU contribution per project (EUR million): 7 - 8
Number of projects expected to be funded: 8

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 2 ‘Living and working in a health-promoting environment’. To that end, proposals under this topic should aim for delivering results that are tailored towards and contributing to all of the following expected outcomes:

• National and EU authorities apply user-friendly tools to produce and use generated data on the impact of pollutants on health;
• National and EU authorities benefit from access to robust and transparent indicators for health impact assessment to monitor efficacy of pollution-mitigating actions and policies;
• Policymakers and other stakeholders, e.g. public authorities such as urban planners, health professionals, employers, civil society organisations and citizens, use developed guidelines to take action to prevent pollution-related illnesses and impairments, and choose healthier lifestyles and behaviours;
• EU, national and regional authorities receive guidance and recommendations for updates of (1) scientific evidence about health risks caused by environmental pollutants (2) advice on management and mitigation of these health risks and (3) guidance and recommendations for updates of limit values for different classes of pollutants in the environment; these recommendations should take into account vulnerable population groups and people with increased vulnerability because of pre-existing medical conditions;
• The implementation of the Zero-Pollution Action Plan, the Chemical Strategy for Sustainability and the EU legislation on air quality, noise and waste continue to be supported by a strong evidence-base;
• Relevant actors in our daily lives, e.g. medical personnel, building engineers, teachers, urban planners etc., have access to information such as training courses on pollution and health impacts.

Code: HORIZON-HLTH-2023-DISEASE-03-06
Action type: CSA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 1
Expected EU contribution per project (EUR million): around 1
Number of projects expected to be funded: 1

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to most of the following expected outcomes:

• Policymakers, funders and other relevant stakeholders135 identify and agree on the governance structure and implementation modalities, allowing for an efficient establishment of a potential future partnership.
• Policymakers, funders and other relevant stakeholders build on the knowledge gathered in past studies performed at EU and national level.
• Policymakers, funders and other relevant stakeholders identify and agree on common research priorities and research needs, also taking into consideration developments at the international level where relevant.
• Policymakers, funders and other relevant stakeholders develop and align national and regional research strategy plans with long-term sustainability in mind.
• Policymakers and funders commit to providing financial support that will allow for a comprehensive, impact-driven structuring of the field of European brain health research.

Code: HORIZON-HLTH-2023-DISEASE-03-07
Action type: RIA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 30
Expected EU contribution per project (EUR million): 6 - 7
Number of projects expected to be funded: 5

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to the following expected outcomes:

• All players along the health care value chain are provided with new knowledge for a better understanding of the links (e.g. causalities) between infectious diseases (IDs) and non-communicable diseases (NCDs) and comorbidities, including knowledge on host risk factors that impact the development of disease progression for NCDs and/or IDs.
• Researchers and clinicians are provided with a robust evidence base that will contribute to the development of new or improved tools to diagnose and prevent the development and aggravation of non-communicable disease(s) as well as early treatment and management of patients suffering from co-morbidities following an infectious disease.
• Healthcare practitioners have access to knowledge to guide them on preventive measures, on early identification of diseases onset and of those patients at risk of developing severe disease progression, and on the optimal treatment of patients.

When NCDs are related to infectious diseases with pandemic potential, healthcare practitioners will be provided with new evidence to help them make informed decision on the management of the diseases in the future. Public health authorities will be better prepared to issue targeted recommendations linked or not to the use of specific medical countermeasures in crisis times.

Code: HORIZON-HLTH-2023-DISEASE-03-17
Action type: RIA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 20
Expected EU contribution per project (EUR million): 7 - 8
Number of projects expected to be funded: 5

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes:

• The scientific and clinical communities have an increased knowledge of vaccine-induced immunity and, in particular, a better understanding of factors that affect the magnitude, breadth, nature and duration of immunity to vaccine antigens.
• The scientific and clinical communities have an increased knowledge of the durability and breadth of vaccine-induced immunity in vulnerable populations and older age groups.
• The scientific and clinical communities have an increased knowledge of correlates of protection for pathogens with epidemic potential to allow the development of effective vaccines.
• The scientific and clinical communities have an increased knowledge of the characteristics that influence vaccine effectiveness to allow for novel approaches for the development of vaccines for emerging and re-emerging infections, including antigenic variants, in the context of epidemic and pandemic preparedness.

Code: HORIZON-HLTH-2023-DISEASE-03-18
Action type: RIA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 50
Expected EU contribution per project (EUR million): 7 - 8
Number of projects expected to be funded: 7

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes:

• The scientific and clinical communities have an increased knowledge on viruses with epidemic and pandemic potential and in particular a better understanding of viral targets for vaccine development.
• The scientific and clinical communities have access to novel approaches for the prevention and treatment for emerging and re-emerging infections in the context of epidemic and pandemic preparedness.
• The scientific and clinical communities have access to experimental vaccine candidates against emerging or re-emerging viral infections for further clinical investigation.
• A diverse and robust pipeline of vaccine candidates is available for emerging and re-emerging viral infections, increasing therapeutic options for clinical deployment in case of an epidemic or pandemic.

Code: HORIZON-HLTH-2023-DISEASE-07-01
Action type: COFUND
Opening: 12 Jan 2023
Deadline: 19 Sep 2023
Budget (EUR million): 50
Expected EU contribution per project (EUR million): around 50
Number of projects expected to be funded: 1

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes:

• The EU is reinforced as an internationally recognised driver of research and innovation in rare diseases (RD) and thereby substantially contributing to the achievement of the Sustainable Development Goals related to rare diseases;
• Research funders align, adopt and implement their RD research policies allowing for the optimal generation and translation of knowledge into meaningful health products and interventions responding to the needs of people living with a rare disease across Europe and globally.
• The RD research community at large benefit from and use an improved comprehensive knowledge framework integrating the EU, national/regional data and information infrastructures to improve translational research.
• People living with a rare disease benefit from a more timely, equitable access to innovative, sustainable and high-quality healthcare, taking stock of highly integrated research and healthcare systems.
• Researchers, innovators - as well as people living with a rare disease and their advocates (as co-creators) - effectively constitute and operate into an integrated research and innovation ecosystem to deliver cost-effective diagnosis and treatments.
• Public and private actors, including civil society (e.g. NGOs, charities), establish coordinated and efficient multi-stakeholder collaborations at EU and national (including regional) levels, allowing for more effective clinical research, for example aiming at improved success rates of therapeutic development.

Code: HORIZON-HLTH-2024-DISEASE-03-08-two-stage
Action type: RIA
Opening: 30 Mar 2023
Deadline: 19 Sep 2023 (First Stage), 11 Apr 2024 (Second Stage)
Budget (EUR million): 45
Expected EU contribution per project (EUR million): 6 - 7
Number of projects expected to be funded: 7

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to most of the following expected outcomes:

• Health policymakers are aware of the healthcare interventions (pharmacological, non-pharmacological or technological interventions; including preventive and rehabilitative actions) that are identified as working best for the specific population groups from the point of view of safety, efficacy, patient outcomes, adherence, quality of life, accessibility, and (cost-) effectiveness.
• Health professionals have access to and use the improved clinical guidelines on the optimal treatment of patients and prevention of diseases e.g. through vaccines. Considerations made in the guidelines include the harmonisation and standardisation of care for high burden diseases or conditions throughout Europe, as well as possible individualised needs of patients.
• The scientific and clinical communities make effective use of state-of-the-art information, data, technologies, tools and best practices to develop interventions that are sustainable.
• Citizens, patients, prescribers, and payers receive more accurate information on available healthcare interventions via ad hoc communication platforms.
• The scientific and clinical communities make wide use of the newly established open access databases and/or integrate them with existing open access infrastructures for storage and sharing of collected data according to FAIR159 principles.

Code: HORIZON-HLTH-2024-DISEASE-03-11-two-stage
Action type: RIA
Opening: 30 Mar 2023
Deadline: 19 Sep 2023 (First Stage), 11 Apr 2024 (Second Stage)
Budget (EUR million): 30
Expected EU contribution per project (EUR million): 8 - 10
Number of projects expected to be funded: 3

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes:

• A diverse and comprehensive EU landscape of multi-country adaptive platform trials (i.e. able to study multiple interventions in a disease or condition in a perpetual manner, thus allowing modification to the trial after its initiation without undermining its validity and integrity) that assess vaccines and therapeutics for infectious diseases, and have the capacity to pivot rapidly in the case of epidemic or pandemic health threats.
• Innovative and improved design of clinical studies, suited for pandemic preparedness, is available for the clinical research community, taking into account the high safety standards in the European regulatory environment.
• Trial sites across multiple countries have the capacity to deliver robust clinical evidence in a diverse European population, using harmonised research methods, data collection and analysis.

Code: HORIZON-HLTH-2024-DISEASE-03-13-two-stage
Action type: RIA
Opening: 30 Mar 2023
Deadline: 19 Sep 2023 (First Stage), 11 Apr 2024 (Second Stage)
Budget (EUR million): 25
Expected EU contribution per project (EUR million): 6 - 8
Number of projects expected to be funded: 3

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to most of the following expected outcomes:

• The scientific and clinical communities make effective use of state-of-the-art information, data, technologies, tools and best practices to underpin the development of the diagnostics, and as such can also facilitate the development of effective therapeutics and/or preventive strategies.
• The scientific and clinical communities advance the field through a better understanding of mechanisms underlying brain disorders at the molecular, cellular and systemic level.
• The scientific and clinical community make wide use of newly established and where relevant open access databases and/or integrate them with existing infrastructures for storage and sharing of collected data according to FAIR167 principles, thereby encouraging further use of the data.
• Policymakers, funders, scientific and clinical communities, patient organisations, regulators and other relevant bodies are informed of the research advances made, while health professionals envisage use of the biomarker tests for early detection of the disorder and for guiding patients in the selection of personalised treatments/interventions.
• Patients and caregivers are sufficiently engaged with the research, which also caters for their needs.

Code: HORIZON-HLTH-2024-DISEASE-03-14-two-stage
Action type: RIA
Opening: 30 Mar 2023
Deadline: 19 Sep 2023 (First Stage), 11 Apr 2024 (Second Stage)
Budget (EUR million): 25
Expected EU contribution per project (EUR million): 6 - 7
Number of projects expected to be funded: 4

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to most of the following expected outcomes:

• The scientific and clinical communities make effective use of state-of-the-art information, data, technologies, tools and best practices to better understand the condition, underpinning the development of diagnostics, therapeutics and/or preventive strategies.
• The scientific and clinical community exchange data, knowledge and best practices, thereby strengthening their collaboration and building knowledge and care networks in Europe and beyond.
• The scientific and clinical community make wide use of newly established and where relevant open access databases and/or integrate them with existing infrastructures for storage and sharing of collected data according to FAIR174 principles, thereby encouraging further use of the data.
• Policymakers and funders are informed of the research advances made and consider further support in light of the sustainability of the studies.
• Patients and caregivers are constructively engaged with the research, which also caters for their needs.
• Health professionals have access to and use improved clinical guidelines on diagnosis and/or treatment of the condition.

Code: HORIZON-HLTH-2024-DISEASE-08-12
Action type: CSA
Opening: 26 Oct 2023
Deadline: 11 Apr 2024
Budget (EUR million): 2
Expected EU contribution per project (EUR million): around 2
Number of projects expected to be funded: 1

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes:

• Research funders, policymakers and the research community maintain a consolidated research and innovation framework for the European partnership for pandemic preparedness, including the Partnership’s objectives, governance and ways of working/operationalisation;
• Research funders, policymakers and the research community are aligned towards common objectives and have a common understanding of the long-term Strategic Research and Innovation Agenda for the Partnership;
• European research funders are supported by a dynamic and efficient secretariat in their coordination efforts for pandemic preparedness research;
• Healthcare providers, European and international stakeholders engage with the appropriate partners through the research and innovation framework for the partnership

Code: HORIZON-HLTH-2024-DISEASE-08-20
Action type: RIA
Opening: 26 Oct 2023
Deadline: 11 Apr 2024
Budget (EUR million): 50
Expected EU contribution per project (EUR million): 7 - 8
Number of projects expected to be funded: 5

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes:

• The scientific and clinical communities have an increased knowledge on viruses with epidemic potential and in particular a better understanding of pathogen–host interactions for the targeted development of vaccines and inhibitors for the prevention of viral infection and the viral transmission during pathogenesis.
• The scientific and clinical communities have access to novel approaches for the prevention and treatment for emerging and re-emerging infections in the context of epidemic and pandemic preparedness.
• The scientific and clinical communities have access to experimental vaccine candidates and candidates that inhibit cellular uptake of viruses against emerging or re-emerging viral infections for further clinical investigation.

Code: HORIZON-HLTH-2024-DISEASE-09-01
Action type: COFUND
Opening: 26 Oct 2023
Deadline: 11 Apr 2024
Budget (EUR million): 100
Expected EU contribution per project (EUR million): around 100
Number of projects expected to be funded: 1

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes:

• The EU’s response to curb antimicrobial resistance (AMR) is improved and the EU is reinforced as an internationally recognised driver of research and innovation on AMR thereby substantially contributing to the achievement of the Sustainable Development Goals related to AMR;
• EU and national agencies, the scientific communities, policymakers and funders enhance their collaboration and coordination for a strengthened ‘One Health (OH) approach to fight antimicrobial resistance (AMR)’ forming a strong and structured ecosystem with shared evidence, tools and methodologies cutting across sectors;
• Research funders, policymakers, relevant agencies and authorities, and the research community are in a position to close the current gaps and break existing silos on AMR in accordance with the European One Health Action Plan against AMR185;
• Research funders align, adopt and implement their research policies and activities allowing for the optimal generation of novel solutions to prevent and treat infectious diseases affected by AMR, improved surveillance and diagnosis and control of the spread of resistant microorganisms, testing and validation of such solutions and facilitating their uptake or implementation responding to the needs to reduce the burden of AMR;
• The EU is strengthened as an internationally recognised actor for OH AMR substantially contributing to global cooperation and coordination by expanding beyond Europe;
• The research community at large benefit from and use an improved comprehensive knowledge framework integrating the EU, national/regional data and information infrastructures to improve transnational research.

Code: HORIZON-HLTH-2024-CARE-04-04-two-stage
Action type: RIA
Opening: 30 Mar 2023
Deadline: 19 Sep 2023 (First Stage), 11 Apr 2024 (Second Stage)
Budget (EUR million): 30
Expected EU contribution per project (EUR million): 4 - 6
Number of projects expected to be funded: 5

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 4 “Ensuring access to innovative, sustainable and high-quality health care”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to several of the following expected outcomes:

• Decision- and policymakers, service providers, and health and care workers have better availability to and make use of knowledge on barriers to access to health and care services226 experienced by people in vulnerable situations and at risk of stigma or discrimination (from now on referred to as people in vulnerable situations)227.
• Decision- and policymakers, providers and health and care workers have access to innovative solutions to promote and improve access to health and care services for people in vulnerable situations.
• Decision- and policymakers and providers have access to reliable quantitative data on health inequalities in access to health and care services for people in vulnerable situations.
• People in vulnerable situations are better equipped in terms of health and digital literacy, knowledge about their rights etc. when it comes to access to health and care services.
• People in vulnerable situations are involved in the design and implementation of research and innovation activities concerning access to health and care services.

Code: HORIZON-HLTH-2023-TOOL-05-04
Action type: RIA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 35
Expected EU contribution per project (EUR million): 8 - 10
Number of projects expected to be funded: 4

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 5 “Unlocking the full potential of new tools, technologies and digital solutions for a healthy society”. To that end, proposals under this topic should aim for delivering results that are directed towards and contributing to most of the following expected outcomes:

• Researchers, innovators and healthcare professionals benefit from better linkage of health data from various sources, including genomics, based on harmonised approaches related to data structure, format and quality, applicable across certain disease areas and across national borders.
• Researchers, innovators, healthcare professionals and health policymakers have access to advanced digital tools for the integration, management and analysis of various health data re-used in a secure, cost-effective and clinically meaningful way enabling the improvement of health outcomes.
• By linking and using effectively more data and new methods and tools, including artificial intelligence, researchers, innovators and healthcare professionals are able to advance our understanding of the risk factors, causes, development and optimal treatment in disease areas where genomics integrated with other health data, spanning from clinical to e.g. lifestyle, offer potential for novel and more comprehensive information.
• Healthcare professionals and health policymakers benefit from data-driven solutions and reinforced evidence base for decisions addressing health and care challenges.
• Citizens can be offered data-driven patient-focused health interventions, resulting in improved disease prevention, diagnosis, treatment and monitoring towards better patient outcomes and well-being.
• Citizens’ trust in the sharing and re-use of health data for research and healthcare increases due to the application of advanced technologies and data governance preserving data privacy and security.

Code: HORIZON-HLTH-2023-TOOL-05-05
Action type: IA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 35
Expected EU contribution per project (EUR million): 8 - 10
Number of projects expected to be funded: 4

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 5 “Unlocking the full potential of new tools, technologies and digital solutions for a healthy society”. To that end, proposals under this topic should aim for delivering results that are directed towards and contributing to all of the following expected outcomes:

• Healthcare professionals benefit from secure, highly performant Point-of-Care computing technologies and devices able to process and analyse vast amounts of real-time data at the point of care, combined with extended reality and visualisation techniques, to enable continuous monitoring and/or fast real-time health status checks in clinical settings and workflows.
• Patients and clinicians benefit from wider access to real-time diagnosis, screening, monitoring and treatments using novel imaging and/or robotics systems and/or Point-of-Care devices that are seamlessly integrated in care environments and workflows.
• Quicker reaction times and improved patient safety in care settings.
• Researchers and healthcare professionals have more opportunities to use, extract value from and contribute to the uptake of real-time health data and/or Point-of-Care computing; existing technologies and methods are expected to progress from their current technology readiness levels (TRL), from TRL 3-4 to at least TRL 7247.
• Health and care settings benefit from reduced energy consumption of Point-of-Care tools, devices and systems, and/or data analysis.

Code: HORIZON-HLTH-2023-TOOL-05-08
Action type: IA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 40
Expected EU contribution per project (EUR million): 5 - 7
Number of projects expected to be funded: 6

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 5 “Unlocking the full potential of new tools, technologies and digital solutions for a healthy society”. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes:

• The scientific and clinical communities, including health care providers and payers, as well as regulators, health systems and patients benefit from innovative diagnostic solutions that are better suited to tackle cross-border health threats.
• The scientific and clinical communities have access to novel and improved methodologies for detection of pathogens with pandemic potential in humans and for timely discovery of other health threats, such as chemical, radiological and nuclear threats, including considerations on detection in animals and environmental conditions (One Health approach).
• A diverse and robust pipeline of in vitro diagnostics248 is available, increasing options for clinical deployment in case of an epidemic or pandemic.

Code: HORIZON-HLTH-2023-TOOL-05-09
Action type: CSA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 4
Expected EU contribution per project (EUR million): around 4
Number of projects expected to be funded: 1

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 5 “Unlocking the full potential of new tools, technologies and digital solutions for a healthy society”. To that end, proposals under this topic should aim to deliver results that are directed towards and contributing to all of the following expected outcomes:

• Data Users (researchers, innovators, regulators, policymakers, clinicians) are able to identify the most relevant datasets that meet their specific needs through a label describing accurately and in a standard way the quality and utility dimensions of the datasets, as proposed in the legal provisions of the European Health Data Space (EHDS).
• Data holders have clear specifications for dataset quality and utility labelling to comply with the requirements proposed in the EHDS legal provisions. In addition to that, data holders have access to a maturity model with the requirements a dataset needs to fulfil to achieve higher levels of data quality and utility.
• European and National public funders ensure that the datasets, for which they provided funding for the creation and curation of, are more widely available, furthering their reuse for secondary uses as proposed in the EHDS legal provisions (research, innovation, regulatory work, policymaking, personalised medicine).
• The European Commission has access to a set of specifications for the data quality and utility label supporting the implementation of the EHDS legal provisions.

Code: HORIZON-HLTH-2024-TOOL-05-06-two-stages
Action type: RIA
Opening: 30 Mar 2023
Deadline: 19 Sep 2023 (First Stage), 11 Apr 2024 (Second Stage)
Budget (EUR million): 25
Expected EU contribution per project (EUR million): 4 - 8
Number of projects expected to be funded: 4

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 5 “Unlocking the full potential of new tools, technologies and digital solutions for a healthy society”. To that end, proposals under this topic should aim for delivering results that are directed towards and contributing to several of the following Expected Outcomes:

• Researchers utilise tools and strategies that are more relevant to the human situation as compared to the currently used animal models.
• Fewer live animals are used in biomedical research.
• Health technology developers will get access to improved human-relevant tools or strategies allowing for a faster pace of innovation.
• Legislators and regulators will benefit from strengthened EU leadership in non-animal based biomedical research that is socially accepted and sustainable.
• Healthcare providers and patients will benefit from innovative tools or strategies opening up novel biomedical concepts enabling improved disease prediction, prevention and treatment.

Code: HORIZON-HLTH-2024-TOOL-11-02
Action type: RIA
Opening: 26 Oct 2023
Deadline: 11 Apr 2024
Budget (EUR million): 25
Expected EU contribution per project (EUR million): 6 - 8
Number of projects expected to be funded: 4

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 5 “Unlocking the full potential of new tools, technologies and digital solutions for a healthy society”. To that end, proposals under this topic should aim for delivering results that are directed towards and contributing to several of the following expected Outcomes:

• Biomedical scientists will access entire bio-printing units for regenerating human tissue.
• Availability of larger-scale bio-printed tissues for biomedical research purposes to both industry and academia.
• Healthcare professionals acquire information on the safe and effective use of advanced therapies.
• Healthcare providers dispose of tools enabling them to treat conditions of unmet medical need.
• Individual patients will benefit from a personalised approach to their respective medical condition thanks to the bio-printed regenerative medicine solution.

Code: HORIZON-HLTH-2023-IND-06-07
Action type: RIA
Opening: 12 Jan 2023
Deadline: 13 Apr 2023
Budget (EUR million): 15
Expected EU contribution per project (EUR million): 7 - 8
Number of projects expected to be funded: 2

Expected Outcome:

This topic aims at addressing digital transition challenges through supporting activities that are enabling or contributing to one or several expected impacts of destination 6 “Maintaining an innovative, sustainable and globally competitive health industry”. More specifically, this topic aims at supporting activities that are contributing to the following impact area: “High quality digital services for all”. To that end, proposals under this topic should aim to deliver results that are directed towards and contributing to all of the following expected outcomes:

• Policymakers in the EU have at their disposal a methodological framework and standardised approaches for assessing digital health technologies, that helps them make evidence-based decisions regarding the introduction of digital health technologies in their health and care systems with added value for patients and society.
• Regulators have access to robust, scientifically underpinned evaluation methodologies.
• EU citizens gain faster access to safe and well-performing person-centred digital technologies and are empowered through these tools.
• Health technology developers are better informed and dispose of more guidance on the evidence needed to demonstrate the added value of digital health technologies and have better insights on market predictability.
• (Digital) Health Industry/digital health technology developers and HTA bodies can contribute to the development of EU harmonised Health Technology Assessment (HTA) rules based on common principles.
• Improved cross-border use and interoperability of digital health tools and services throughout the EU and Associated Countries.
• Increased trust in digital health technologies and better integration of digital health tools and services in health and care systems.

Code: HORIZON-HLTH-2024-IND-06-08
Action type: RIA
Opening: 26 Oct 2023
Deadline: 11 Apr 2024
Budget (EUR million): 10
Expected EU contribution per project (EUR million): 8 - 10
Number of projects expected to be funded: 1

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 6 “Maintaining an innovative, sustainable and globally competitive health industry”. To that end, proposals under this topic should aim to deliver results that are directed, tailored towards and contributing to all of the following expected outcomes:

• Patients gain faster access to innovative, safe and well-performing medical devices;
• Regulators have access to sound scientific resources for clinical/performance evaluation guidance and development of common specifications as foreseen in Article 9 of the Medical Device Regulation (MDR);
• Notified bodies, by their direct participation to the production of documents, will have a harmonised way of assessing the clinical evidence in the pre-market and post-market phases; furthermore their network277, will be enhanced;
• Health technology developers gain insight on the evidence needed to demonstrate that their devices meet MDR clinical requirements throughout their lifetime. They will also have more guidance on the use of real-world data for their clinical development strategies.

Code: HORIZON-HLTH-2024-IND-06-09
Action type: CSA
Opening: 26 Oct 2023
Deadline: 11 Apr 2024
Budget (EUR million): 2
Expected EU contribution per project (EUR million): around 2
Number of projects expected to be funded: 1

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 6 “Maintaining an innovative, sustainable and globally competitive health industry”. To that end, proposals under this topic should aim to deliver results that are directed, tailored towards and contributing to all of the following expected outcomes:

• European regulators gain state-of-the-art knowledge on different NAMs that are being proposed for the assessment of the safety and efficacy of chemicals and pharmaceuticals;
• European regulators understand better the shortcomings of the current tools based on animal procedures for the assessment of chemicals and pharmaceuticals;
• European regulators collaborate on a framework on how to assess the safety of chemicals based on NAM-data and how to classify the hazardous properties based on such data;
• European regulators collaborate on a similar framework for assessment of safety and efficacy of pharmaceuticals based on NAM-data;
• Citizens benefit from the supply and use of chemicals and pharmaceuticals that have been assessed through NAMs that are better predicting potential effects in humans than the current assessment methods;
• Industry has an improved competitive position with the availability of harmonised and standardised NAM-based assessment tools that are faster and more flexible;
• European Commission and Member States regulators are responding to the societal demand to move away from animal testing.