Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
-
Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 328
2020
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One-pot synthesis of natural amine-modified biocompatible carbon quantum dots with antibacterial activity
Journal of Colloid and Interface Science, rok: 2020, ročník: 580, vydání: NOV, DOI
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OPTIMIZATION OF EXPRESSSION AND PURIFICATION OF FRAGMENT FROM TAU PROTEIN
Rok: 2020, druh: Konferenční abstrakty
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Phosphomimicking mutants: why to be careful
Rok: 2020, druh: Konferenční abstrakty
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Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin Kinase 2
Molecular Biology of the Cell, rok: 2020, ročník: 31, vydání: 10, DOI
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Preparation of thorium dioxide nanofibers by electrospinning
Journal of Nuclear Materials, rok: 2020, ročník: 534, vydání: JUN 2020, DOI
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RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer
EMBO Journal, rok: 2020, ročník: 39, vydání: 18, DOI
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Structural Basis of Ca2+-Dependent Self-Processing Activity of Repeat-in-Toxin Proteins
MBIO, rok: 2020, ročník: 11, vydání: 2, DOI
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Structure and mechanism of DNA delivery of a gene transfer agent
Nature Communications, rok: 2020, ročník: 11, vydání: 1, DOI
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The Beta Subunit of Nascent Polypeptide Associated Complex Plays A Role in Flowers and Siliques Development of Arabidopsis thaliana
International Journal of Molecular Sciences, rok: 2020, ročník: 21, vydání: 6, DOI
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The Effect of Synthesis Procedure on Hydrogen Peroxidase-Like Catalytic Activity of Iron Oxide Magnetic Particles
Applied Sciences-Basel, rok: 2020, ročník: 10, vydání: 19, DOI